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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

HL60 and K562 cell

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

4

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N12153
    Theasaponin E2

    		Others Cancer
    Theasaponin E2 shows cytotoxicity against K562 and HL60 cells (IC50: 14.7 μg/mL). Theasaponin E2 can be isolated from Camellia sinensis .
    Theasaponin E2
  • HY-155390
    Caspase-3 activator 3

    		Caspase Apoptosis Cancer
    Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC50 values of 42.89 and 33.61 μM, respectively .
    Caspase-3 activator 3
  • HY-N9339
    Norglaucine

    (+)-Norglaucine

    		 Others Cancer
    Norglaucine ((+)-Norglaucine), a cytotoxic alkaloid, exhibits cytotoxicity towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .
    Norglaucine
  • HY-155389
    Caspase-3 activator 2

    		Caspase Cancer
    Caspase-3 activator 2 (Compound 2f) is a caspase 3 activator that induces apoptosis and can be used in cancer research. Caspase-3 activator 2 is cytotoxic to HL-60 cells and K562 cells, with IC50 values of 33.52 μM and 76.90 μM respectively .
    Caspase-3 activator 2
  • HY-149470
    MOZ-IN-3

    		Histone Acetyltransferase Cancer
    MOZ-IN-3 (Compound 6j) is a KAT6A (MOZ) acetyltransferase inhibitor (IC50: 30 nM). MOZ-IN-3 has antitumor activity against four different myeloid leukemia cell lines (HL-60, U937, SKNO-1, K562). MOZ-IN-3 has favorable metabolic stability and pharmacokinetics .
    MOZ-IN-3
  • HY-N11709
    Theasaponin E1

    		Others Cancer
    Theasaponin E1 is a tea saponin isolated from tea seeds. Theasaponin E1 exhibits potential antitumor activity against human tumor cell lines K562 and HL60. Theasaponin E1 also has quinone reductase (QR)-inducing activity and can act as an anti-tumor agent for cancer prevention .
    Theasaponin E1
  • HY-156016
    HDAC/CD13-IN-1

    		HDAC Cancer
    HDAC/CD13-IN-1 (Compound 12) is a HDAC/CD13 inhibitor (IC50: 0.34 μM for hCD13, 0.53 μM for porcine CD13, 0.03, 0.06, 0.02 μM for HDAC1/2/3). HDAC/CD13-IN-1 inhibits MV4-11, K562, Jeko-1, and HL60 cell proliferation (IC50: 0.25-2.04 μM). HDAC/CD13-IN-1 induces cancer cell apoptosis. HDAC/CD13-IN-1 has anti-metastasis and anti-invasion efficacy .
    HDAC/CD13-IN-1
  • HY-N11576
    Secalonic acid D

    		Apoptosis GSK-3 c-Myc β-catenin Cancer
    Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis .
    Secalonic acid D

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